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Comparison of two and ten per cent rectal methohexitone for induction of anaesthesia in children
1Department of Anesthesia, University of Iowa College of Medicine, Iowa City 52242.
Insights
Rectal methohexitone at a two percent concentration led to higher plasma concentrations in children compared to a ten percent solution. This difference was significant up to 45 minutes post-administration.
Area of Science:
- Anesthesiology
- Pediatric Pharmacology
- Pharmacokinetics
Background:
- Rectal methohexitone is utilized for pediatric anesthesia induction.
- Understanding the pharmacokinetic profile of different rectal solution concentrations is crucial for optimizing drug delivery and patient safety.
Purpose of the Study:
- To compare plasma methohexitone concentrations following rectal administration of two percent versus ten percent solutions in children.
- To evaluate the impact of rectal solution concentration on the induction of anesthesia in pediatric patients.
Main Methods:
- Thirty children aged one to six years received 25 mg/kg rectal methohexitone as either a two percent or ten percent solution.
- Plasma methohexitone concentrations were measured at 15, 30, 45, and 120 minutes post-administration.
- Time to sleep and clinical efficacy were also observed.
Main Results:
- Twenty-six of thirty children achieved sleep within 15 minutes.
- Mean plasma methohexitone concentrations were significantly higher at 15, 30, and 45 minutes following administration of the two percent solution compared to the ten percent solution.
- Concentrations at 120 minutes were similar between the two groups.
Conclusions:
- The two percent rectal methohexitone solution results in higher initial plasma concentrations in pediatric patients compared to the ten percent solution.
- This suggests a potential difference in absorption rates or bioavailability based on concentration, impacting early anesthetic effect.
Abstract:
Plasma methohexitone concentrations were determined in 30 children, aged one to six years, who received 25 mg.kg-1 rectal methohexitone as either a two per cent or ten per cent solution for induction of anaesthesia. Venous blood samples were obtained 15, 30, 45 and 120 minutes following drug administration. Twenty-six of 30 children were asleep within fifteen minutes. Mean plasma methohexitone concentrations were 5.39, 4.42, 3.40 and 1.54 micrograms.ml-1 at 15, 30, 45 and 120 minutes following administration of two per cent methohexitone. Use of the ten per cent solution resulted in mean plasma methohexitone concentrations of 3.81, 3.12, 2.31 and 1.07 micrograms.ml-1 at the same time intervals. Plasma methohexitone concentrations were significantly higher at 15, 30 and 45 minutes following administration of two per cent methohexitone, when compared to the ten per cent solution.