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Updated: Nov 4, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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[Risk factors for neonatal congenital hypothyroidism: a Meta analysis]

Ji Zhang1, Yang Li1

  • 1Institute of Endemic Disease, Guizhou Provincial Center for Disease Prevention and Control, Guiyang 550004, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|May 22, 2021
PubMed

Insights

This study identified key risk factors for congenital hypothyroidism (CH) in newborns. Advanced maternal age, maternal health conditions, and birth complications significantly increase the risk of CH.

Area of Science:

  • Neonatal Health
  • Endocrinology
  • Public Health

Background:

  • Congenital hypothyroidism (CH) is a common endocrine disorder in neonates.
  • Identifying risk factors is crucial for effective prevention strategies.

Purpose of the Study:

  • To investigate risk factors associated with congenital hypothyroidism (CH) in neonates.
  • To provide a reference for CH prevention.

Main Methods:

  • A meta-analysis was conducted on 20 studies (13 case-control, 7 cross-sectional) published up to August 1, 2020.
  • Searched multiple Chinese and international databases.
  • Utilized R 3.6.2 and RevMan 5.3 software for analysis.

Main Results:

  • Advanced maternal age, maternal thyroid disease, gestational diabetes mellitus, and anxiety were significant risk factors.
  • Medication use, radiation exposure, and family history of thyroid disease also increased CH risk.
  • Low birth weight, fetal macrosomia, preterm birth, post-term birth, twin/multiple pregnancies, and birth defects were identified as risk factors.

Conclusions:

  • Several maternal and neonatal factors are associated with an increased risk of congenital hypothyroidism.
  • These findings can inform targeted interventions and preventative measures for CH.
Abstract

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