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Related Experiment Video

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The Motor Basis for Misophonia.

Sukhbinder Kumar1, Pradeep Dheerendra2, Mercede Erfanian3

  • 1Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom Sukhbinder.kumar@ncl.ac.uk.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 22, 2021
PubMed
Summary

Misophonia, a disorder triggered by everyday sounds, may stem from hyper-mirroring of orofacial movements, not sound processing itself. This suggests therapies should target motor system activity rather than just auditory triggers.

Keywords:
auditoryfMRImirror neuronsmisophoniamotor systemresting state connectivity

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Auditory Processing

Background:

  • Misophonia is a disorder causing strong negative emotions in response to specific sounds.
  • The exact cause of misophonia remains unknown.
  • Trigger sounds often involve orofacial movements, suggesting a link to the mirror neuron system.

Purpose of the Study:

  • To investigate the role of the mirror neuron system in misophonia.
  • To compare brain activity and connectivity in misophonia sufferers and controls.

Main Methods:

  • Resting-state fMRI (rs-fMRI) connectivity analysis.
  • Sound-evoked fMRI responses.
  • Comparison between misophonia patients (N=42) and controls (N=33).

Main Results:

  • Misophonia patients showed no difference in auditory cortex responses to trigger sounds.
  • Increased rs-fMRI connectivity between auditory/visual cortex and ventral premotor cortex in misophonia.
  • Enhanced functional connectivity between auditory cortex and orofacial motor areas.
  • Greater activation of the orofacial motor area in response to trigger sounds.

Conclusions:

  • Misophonia may be characterized by "hyper-mirroring" of orofacial actions, with sounds acting as a medium.
  • The disorder is linked to motor system activity rather than sound perception alone.
  • This framework suggests therapies should focus on motor system representations for effective treatment.