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The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

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Updated: Nov 4, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

DNA origami single crystals with Wulff shapes.

Yong Wang^1,2, Lizhi Dai^1,2, Zhiyuan Ding¹

¹National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, China.

Nature Communications

|May 22, 2021

Summary

Researchers created DNA origami single crystals with precise Wulff shapes. These novel structures enable the formation of robust silica-DNA hybrid materials, advancing nanoscale fabrication and material science.

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Last Updated: Nov 4, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

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Published on: March 5, 2019

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Published on: May 8, 2015

Area of Science:

Nanotechnology
Materials Science
Biophysics

Background:

DNA origami enables precise 3D manipulation of molecules and colloids.
Fabricating single crystals with defined facets from complex DNA origami units presents a significant challenge.

Purpose of the Study:

To report the successful fabrication of DNA origami single crystals with Wulff shapes.
To demonstrate the controlled design of crystalline shapes by regulating DNA origami building blocks.
To develop mechanically reinforced silica-DNA hybrid structures using these crystals.

Main Methods:

Designing DNA origami building blocks with specific symmetries and binding modes.
Inducing controlled silica growth on the edges of DNA origami single crystals.
Analyzing silica-infused microcrystals using high-resolution electron microscopy and tomographic 3D reconstruction.

Main Results:

Achieved high-yield fabrication of DNA origami single crystals with Wulff shapes.
Demonstrated precise control over crystalline shapes through building block design.
Created mechanically reinforced silica-DNA hybrid structures that accurately preserve crystal details.

Conclusions:

DNA origami technology can be effectively used to create well-defined single crystals.
The resulting silica-DNA hybrid structures offer enhanced mechanical properties and detailed structural preservation.
This method facilitates advanced analysis of nanoscale crystalline structures.