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Ventilation abnormalities associated with pulmonary embolism.

M S Sandler1, M G Velchik, A Alavi

  • 1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.

Clinical Nuclear Medicine
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

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Pulmonary embolism can occur with abnormal lung ventilation and perfusion scans. Matching defects on ventilation/perfusion scans may indicate pulmonary embolism without infarction, requiring further investigation.

Area of Science:

  • Radiology
  • Pulmonary Medicine
  • Diagnostic Imaging

Background:

  • Pulmonary embolism (PE) is a significant cause of morbidity and mortality.
  • Ventilation/perfusion (V/Q) imaging is a key diagnostic tool for PE.
  • The interpretation of V/Q scans in the context of abnormal ventilation requires careful consideration.

Purpose of the Study:

  • To investigate the association between abnormal ventilation and pulmonary embolism.
  • To determine the significance of matching ventilation/perfusion defects in suspected PE.
  • To evaluate the diagnostic utility of V/Q scans in specific clinical scenarios.

Main Methods:

  • Retrospective analysis of 2035 lung imaging studies over approximately 5 years.
  • Identification of patients with coexisting abnormal ventilation and pulmonary embolism.

Related Experiment Videos

  • Correlation of V/Q scan findings with clinical suspicion and diagnostic outcomes.

    • Main Results:

    • Abnormal ventilation was found concurrently with pulmonary embolism in 18 patients.
    • Matching ventilation/perfusion defects were observed in PE cases without infarction.
    • A high clinical suspicion of PE with matching V/Q abnormalities suggested the need for definitive imaging.

    Conclusions:

    • Abnormal ventilation can coexist with pulmonary embolism.
    • Matching V/Q defects may indicate PE without infarction.
    • Angiography may be required for definitive PE diagnosis when V/Q scans show matching abnormalities and clinical suspicion is high.