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WITHDRAWN: Malignancy is a risk factor for higher COVID-19 severity:A meta-analysis
Turkish Journal of Medical Sciences
|May 23, 2021
Summary
Patients with cancer (malignancy) face a higher risk of severe outcomes from COVID-19. This study found malignancy is linked to a 2.3-fold increased risk of critical illness from the novel coronavirus.
Area of Science:
- Oncology
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic.
- Malignancy is a leading cause of mortality worldwide.
- The relationship between malignancy and COVID-19 severity is unclear.
Purpose of the Study:
- To determine the prevalence of malignancy in COVID-19 patients.
- To investigate the association between malignancy and COVID-19 severity.
Main Methods:
- Systematic literature search of PubMed, Web of Sciences, and Embase databases.
- Inclusion of 29 studies with 9475 confirmed COVID-19 patients.
- Data analysis using Stata 15.0.
Main Results:
- The overall proportion of malignancy among COVID-19 patients was 2.5%.
- Malignancy prevalence was higher in severe/critical COVID-19 cases (3.9%) compared to non-severe cases (1.4%).
- Pre-existing malignancy increased the risk of severe/critical COVID-19 by over twofold (OR 2.25).
Conclusions:
- Malignancy is associated with a significantly higher risk of severe/critical COVID-19.
- Malignancy may serve as a clinical predictor for adverse COVID-19 outcomes.
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