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Related Experiment Video

Updated: Nov 4, 2025

Inducing Apical Periodontitis in Mice
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VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation.

Bo Ren1, Que Feng1, Shan He1

  • 1Department of Stomatology, the Fourth Medical Center, Chinese PLA General Hospital, No. 51 Fucheng Road, Beijing, 100048, Haidian District, China.

Journal of Inflammation (London, England)
|May 23, 2021
PubMed
Summary

Vascular Endothelial Growth Factor (VEGF) is significantly elevated in periodontitis patients, indicating its role in disease development. Anti-VEGF therapies show promise for treating periodontitis.

Keywords:
ClinicalDevelopmentFunctionPeriodontitisVEGF

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Area of Science:

  • Periodontology
  • Molecular Biology
  • Biomedical Research

Background:

  • Vascular Endothelial Growth Factor (VEGF) is a key regulator of angiogenesis and has therapeutic applications.
  • The specific role of VEGF in periodontitis, a common inflammatory gum disease, lacks comprehensive systematic evidence.
  • This study aims to systematically evaluate the association between VEGF and periodontitis.

Purpose of the Study:

  • To comprehensively analyze the role of VEGF in patients diagnosed with periodontitis.
  • To determine if VEGF levels are significantly different in periodontitis patients compared to healthy individuals.
  • To explore potential therapeutic implications of targeting VEGF in periodontitis.

Main Methods:

  • A systematic literature search was conducted across multiple databases.
  • Meta-analysis techniques, including standardized mean difference (SMD) and odds ratio (OR) with 95% confidence intervals (CI), were used to assess effect sizes.
  • Clinical data validation through microarray analysis and pathway/process enrichment analysis were performed.

Main Results:

  • The analysis included 16 studies, revealing significantly higher VEGF expression in periodontitis patients versus healthy controls (OR = 16.64, P < 0.001; SMD = 2.25, P < 0.001).
  • Subgroup analyses confirmed the correlation between VEGF and periodontitis in Asian and European populations, but not with age, gender, or pathological type.
  • A large clinical dataset (427 patients, 136 controls) further validated elevated VEGF in periodontitis (P = 0.023).
  • VEGF was found to be involved in crucial biological processes including blood vessel development, growth factor response, cell proliferation, and cell adhesion.

Conclusions:

  • Elevated VEGF levels are strongly associated with the development of periodontitis.
  • Targeting VEGF with anti-VEGF therapies presents a potentially valuable therapeutic strategy for clinical periodontitis management.