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The rotating rodent: a two component system?

C J Pycock, C D Marsden

    European Journal of Pharmacology
    |January 15, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The rotating rat model requires both nigrostriatal and mesolimbic dopamine pathways for activity. Imbalance in striatal dopamine causes asymmetry, while mesolimbic stimulation drives locomotion.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • The rotating rat model is used to study motor activity.
    • Dopamine pathways are crucial for motor control.

    Purpose of the Study:

    • To test the hypothesis that rotating rat activity requires both nigrostriatal and mesolimbic dopaminergic components.
    • To investigate the roles of specific dopamine pathways in circling behavior and motor activity.

    Main Methods:

    • Unilateral 6-hydroxydopamine lesions were induced in nigrostriatal and mesolimbic dopamine pathways.
    • Electrolytic lesions of the nucleus accumbens were performed bilaterally.
    • Circling behavior and drug-induced motor activity were recorded.

    Main Results:

    • Circling behavior occurred only when striatal dopamine imbalance was combined with limbic dopamine stimulation.

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  • Mesolimbic pathway lesions altered drug-induced motor activity but did not cause circling behavior or postural asymmetry.
  • Results support a dual-component model for rotating rat activity.

    • Conclusions:

    • The rotating rat model necessitates two functional dopamine components: striatal for postural asymmetry and mesolimbic for locomotion.
    • This model's relevance is discussed concerning dopaminergic drugs.