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Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice
Young-Jin Jang1, Adithan Aravinthan1, Mohammad Amjad Hossain1
1College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan-city, Jeollabuk-Do, Republic of Korea.
Abstract:
Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.
