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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Multifunctional biomolecule nanostructures for cancer therapy.

Jing Wang^1,2, Yiye Li^1,2, Guangjun Nie^1,2,3,4

¹CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China.

Nature Reviews. Materials

|May 24, 2021

Summary

This summary is machine-generated.

Biomolecule-based nanostructures offer versatile platforms for cancer nanomedicine. Their programmable properties enable smart drug delivery, targeted therapies, and combinatorial treatments, addressing key challenges in clinical translation.

Keywords:

Cancer therapy Nanotechnology in cancer

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Area of Science:

Biomaterials Science
Nanomedicine
Cancer Therapy

Background:

Biomolecule-based nanostructures possess inherent multifunctionality and biological activities.
Their supramolecular properties allow precise programming for advanced nanomedicine applications.

Purpose of the Study:

To review biomolecule-based nanostructures for cancer nanomedicine.
To highlight their design space, biological activities, and in vivo behavior.
To identify challenges and opportunities for clinical translation.

Main Methods:

Review of literature on biomolecule-based nanostructures (polysaccharides, nucleic acids, peptides, proteins).
Analysis of design space, programmability, and in vivo behavior.
Identification of challenges in design, characterization, fabrication, and clinical translation.

Main Results:

Biomolecule-based nanostructures offer vast design potential for multifunctional nanomedicines.
These nanostructures enable efficient in vivo transport, targeted drug delivery, and combinatorial therapy.
Key challenges in cancer nanomedicine can be addressed by these advanced materials.

Conclusions:

Biomolecule-based nanostructures represent a promising frontier in cancer nanomedicine.
Overcoming challenges in rational design, characterization, and fabrication is crucial for clinical translation.
Further research is needed to fully realize their therapeutic potential.