Related Experiment Video
Updated: Nov 4, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Encephalitis: A rare complication of mediterranean spotted fever
Jorge Bastos Mendes1, João Filipe Gomes1, Tatiana Gonçalves1
1Internal Medicine in Centro Hospitalar e Universitário de Coimbra, Portugal.
Abstract:
Mediterranean spotted fever (MSF) is an emerging zoonosis caused by Rickettsia conorii. The MSF typically presents with a triad of fever, generalized cutaneous rash and inoculation eschar, but its clinical spectrum may range from a mild febrile illness to a potentially life-threatening condition, being central nervous system involvement highly rare. We report the clinical case of a 63-year-old male patient with MSF complicated by acute encephalitis and multi-organic failure.
Insights
Mediterranean spotted fever (MSF), caused by Rickettsia conorii, is an emerging zoonosis. This case highlights a rare complication of acute encephalitis and multi-organ failure in an MSF patient.
Area of Science:
- Infectious Diseases
- Neurology
- Public Health
Background:
- Mediterranean spotted fever (MSF) is an emerging zoonosis transmitted by ticks, caused by Rickettsia conorii.
- MSF typically manifests with fever, rash, and an eschar, but can present with diverse clinical symptoms.
Observation:
- A 63-year-old male presented with symptoms indicative of MSF.
- The patient developed severe complications, including acute encephalitis and multi-organ failure.
Findings:
- This case report details a rare presentation of Rickettsia conorii infection.
- Central nervous system involvement and multi-organ failure are uncommon but severe complications of MSF.
Implications:
- This case underscores the importance of recognizing atypical presentations of MSF.
- Early diagnosis and management are crucial for improving outcomes in severe Rickettsia conorii infections.
- Further research into the neuroinvasive potential of Rickettsia conorii is warranted.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Fungal Phylum Microsporidia
Myocarditis II: Clinical Features and Diagnostic Tests
Endocarditis I: Introduction
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Endocarditis III: Medical Management

