Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 4, 2025

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.7K

Molecular diagnosis in cat allergy.

Florin-Dan Popescu1, Carmen Saviana Ganea1, Carmen Panaitescu2

  • 1Department of Allergology and Clinical Immunology, "Nicolae Malaxa" Clinical Hospital, Bucharest 022441, Romania.

World Journal of Methodology
|May 24, 2021
PubMed
Summary

Cat allergy diagnosis is crucial due to widespread allergens. Molecular diagnostics improve accuracy by analyzing specific allergen components, aiding in personalized treatment for cat allergy sufferers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Exposure to Ragweed and House Dust Mite Exacerbates Airway Epithelial Barrier Dysfunction: A Multimodal Approach.

Medicina (Kaunas, Lithuania)·2026
Same author

Availability and Costs of Allergic Rhinitis Treatments Across the World: A Survey of ARIA Experts.

Allergy·2026
Same author

Airborne Ragweed (<i>Ambrosia artemisiifolia</i>) Allergen Exposure and Sensitization Pattern in Western Romania: A 5-Year Retrospective Cross-Sectional Observational Analysis of Sensitization Prevalence, Complemented by a Parallel Temporal Analysis of Aerobiological Data and Symptom-Driven Healthcare Presentation Patterns Study.

Life (Basel, Switzerland)·2026
Same author

Molecular Biomarkers in IgE Immunoassays Used for Grass Pollen Allergy Diagnosis in European Clinical Settings.

International journal of molecular sciences·2026
Same author

Microbiota-Driven Immune Dysregulation Along the Gut-Lung-Vascular Axis in Asthma and Atherosclerosis.

Biomedicines·2026
Same author

Endotype-driven decisions in choosing a biologic for airway diseases.

Frontiers in allergy·2026

Area of Science:

  • Immunology
  • Allergology
  • Molecular Diagnostics

Background:

  • Domestic cats are a primary source of indoor allergens, causing allergic reactions from mild rhinoconjunctivitis to severe asthma.
  • Cat allergens are persistent and widespread in households globally.
  • Standard allergy tests using natural cat dander extracts can vary in allergen component quality and quantity.

Purpose of the Study:

  • To highlight the importance of in vitro diagnosis in cat allergy.
  • To discuss the role of component-resolved diagnosis (CRD) using specific allergen molecules.
  • To evaluate the benefits of molecular-based diagnostics for cat allergy.

Main Methods:

  • Utilizing singleplex and multiplex specific immunoglobulin (Ig) E assays for component-resolved diagnosis.
Keywords:
AllergensComponent-resolved diagnosisFelineImmunoassaysImmunoglobulin E

More Related Videos

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.6K
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.1K

Related Experiment Videos

Last Updated: Nov 4, 2025

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.7K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.6K
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.1K
  • Analyzing key cat allergens including Fel d 1, Fel d 4, Fel d 7, and Fel d 2.
  • Considering the impact of IgA Fel d 5 and IgM Fel d 6, and the galactose-α1,3-galactose epitope.

    • Main Results:

    • Component-resolved diagnosis offers a more precise evaluation compared to natural extracts.
    • Specific allergens like Fel d 1, Fel d 4, Fel d 7, and Fel d 2 are key targets in molecular diagnostics.
    • Native feline allergens IgA Fel d 5 and IgM Fel d 6, binding to galactose-α1,3-galactose, can influence diagnostic outcomes.

    Conclusions:

    • Molecular-based diagnostics provide superior accuracy in identifying specific cat allergens.
    • Understanding individual allergen sensitization is vital for effective cat allergy management.
    • Future research will continue to refine molecular diagnostics with new discoveries.