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Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium
Zehao Jing1,2,3, Renhua Ni1,2, Jiedong Wang1,2,3
1Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Bioactive Materials
|May 24, 2021
Summary
New 3D-printed titanium implants loaded with cisplatin and hydrogel offer a dual solution for osteosarcoma bone defects. These implants effectively reduce tumor size while promoting bone repair, improving patient quality of life.
Area of Science:
- Biomaterials Science
- Orthopedic Oncology
- Drug Delivery Systems
Background:
- Osteosarcoma treatment faces challenges with bone defects, local recurrence, and chemotherapy side effects.
- Traditional implants have limitations in bone repair and drug delivery.
- 3D-printed titanium alloy (Ti6Al4V) implants offer enhanced properties for bone repair and drug loading.
Purpose of the Study:
- To develop and evaluate 3D-printed Ti6Al4V implants loaded with cisplatin and a thermo-sensitive hydrogel.
- To create a bone substitute with combined anti-osteosarcoma and bone-repair functions.
- To assess the efficacy and safety of these implants in preclinical models.
Main Methods:
- Determined optimal cisplatin concentrations (0.8 and 1.6 mg/mL) in vitro.
- Loaded cisplatin/hydrogel into 3D-printed Ti6Al4V implants.
- Evaluated anti-tumor effects and biosafety in tumor-bearing mice.
- Assessed bone repair potential in bone defect rabbit models.
Main Results:
- Cisplatin loading significantly reduced tumor volume by over two-thirds with minimal organ damage.
- Implants demonstrated good biosafety, avoiding systemic cisplatin adverse effects.
- Initial bone repair was slightly hindered at 4 weeks but showed no difference at 8 weeks.
- Implants exhibited acceptable long-term stability with significant bone in-growth and osseointegration.
Conclusions:
- Cisplatin/hydrogel-loaded 3D-printed Ti6Al4V implants are a safe and effective treatment for osteosarcoma-induced bone defects.
- This approach offers improved anti-tumor efficacy and bone repair compared to conventional methods.
- These implants show promise for clinical application in osteosarcoma management.
