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Updated: Nov 4, 2025

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Decreased maximal cortisol secretion rate in patients with cirrhosis: Relation to disease severity

Christina M Lovato1, Thierry Thévenot2, Sophie Borot3

  • 1Department of Internal Medicine/Endocrinology, Diabetes and Metabolism, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

JHEP Reports : Innovation in Hepatology
|May 24, 2021
PubMed
Abstract

Keywords:
ACLF, acute-on-chronic liver failureACTH, adrenocorticotrophinAI, adrenal insufficiencyAdrenal insufficiencyCBG, corticosteroid-binding globulinCIRCI, critical illness-related corticosteroid insufficiencyCP, Child-PughCPR, cortisol production rateCRP, C-reactive proteinCRT, corticosteroid replacement therapyCSR, cortisol secretion rateCSRbase, basal CSR (before ACTH stimulation)CSRmax, maximal CSRComputer-assisted numerical analysisHPA, hypothalamic–pituitary–adrenalHSD, hydroxysteroid dehydrogenaseHydrocortisoneINR, international normalised ratioLiver diseaseMCR, metabolic clearance rateMELD, model for end-stage liver diseaseMetabolic clearance ratePAI, primary adrenal insufficiencyRAI, relative adrenal insufficiencyRCT, randomised clinical trialSAI, secondary adrenal insufficiencySCOTCH, Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of SepsisSTB, standardised beta

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