Cross-tolerance between amineptine, an atypical antidepressant and cocaine in mice

The effects of amineptine and cocaine on locomotor activity were studied in two sets of experiments, by using C57BL/6 mice. In a first set, activity enhancements were evident following acute administration of both drugs. In addition to that the effects of amineptine were additive with those of cocaine. In a second set of experiments, mice developed tolerance to the stimulatory effects of both amineptine and cocaine, and a clear cross-tolerance effect was evident in mice chronically injected with these drugs. The results are discussed in terms of the involvement of dopaminergic mechanisms in the activity stimulating action of amineptine.