Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pyroglutamic acid improves learning and memory capacities in old rats.

F Drago1, C Valerio, V D'Agata

  • 1Institute of Pharmacology, University of Catania Medical School, Italy.

Functional Neurology
|April 1, 1988
PubMed
Summary

The arginine salt of pyroglutamic acid (PCA) enhances learning and memory in aged rats. This compound improved both active and passive avoidance behaviors, suggesting potential cognitive benefits for aging populations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intermediate dose enoxaparin in hospitalized patients with moderate-severe COVID-19: a pilot phase II single-arm study, INHIXACOVID19.

BMC infectious diseases·2023
Same author

Pityriasis lichenoides chronica after BNT162b2 Pfizer-BioNTech vaccine: A novel cutaneous reaction after SARS-CoV-2 vaccine.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Comment on "Pityriasis rosea in a COVID-19 Pediatric Patient".

Actas dermo-sifiliograficas·2022
Same author

Long-term assessment of clinical outcomes and disease progression in patients with corrected Tetralogy of Fallot.

European review for medical and pharmacological sciences·2021
Same author

Comment on "Pityriasis rosea in a COVID-19 Pediatric Patient".

Actas dermo-sifiliograficas·2021
Same author

[Comment on «Pityriasis rosea in a COVID-19 Pediatric Patient»].

Actas dermo-sifiliograficas·2021

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Aging is associated with cognitive decline, impacting learning and memory.
  • Pyroglutamic acid (PCA) is a compound with potential neuroactive properties.
  • Investigating interventions to mitigate age-related cognitive impairment is crucial.

Purpose of the Study:

  • To evaluate the effects of the arginine salt of pyroglutamic acid (PCA) on learning and memory in aged rats.
  • To determine the efficacy of PCA in improving cognitive functions related to active and passive avoidance behaviors.

Main Methods:

  • A subchronic treatment schedule involving intraperitoneal injections of PCA (0.1 and 1 g/kg/day for 15 days) in old rats.
  • Assessment of active avoidance behavior acquisition and extinction using a pole-jumping test.

Related Experiment Videos

  • Evaluation of passive avoidance response retention via a step-through passive avoidance task.

    • Main Results:

    • PCA administration facilitated the acquisition of the pole-jumping response.
    • PCA treatment inhibited the extinction of the active avoidance response, with higher potency at 1 g/kg.
    • Improved retention of the passive avoidance response was observed following PCA treatment.

    Conclusions:

    • The arginine salt of pyroglutamic acid (PCA) demonstrates significant behavioral activity in aged rats.
    • PCA effectively improves learning and memory capacities, as evidenced by enhanced avoidance behaviors.
    • These findings suggest PCA as a potential therapeutic agent for age-related cognitive decline.