Telomerase reverse transcriptase mutation and the p53 pathway in T1 urinary bladder cancer
Staffan Jahnson1, Peter Söderkvist2, Firas Aljabery1
1Division of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
BJU International
|May 24, 2021
Summary
In T1 urinary bladder cancer (UBC), TERT and p53 mutations influence tumor progression. TERT mutations may offer protection against p53-induced progression, warranting further study.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genetics
Background:
- Telomerase reverse transcriptase (TERT) and p53 are critical in tumor proliferation.
- The interplay between TERT and p53 mutations in T1 urinary bladder cancer (UBC) is not fully understood.
Purpose of the Study:
- To investigate the association between TERT mutations, p53 pathway alterations, and tumor progression in T1 UBC.
- To explore the relationship between TERT and p53 mutations and their impact on time to progression.
Main Methods:
- Prospective, population-based study of 158 T1 UBC patients (1992-2001).
- Assessed TERT and p53 mutations, and p53 immunohistochemistry (IHC) with 50% positivity threshold (p53 IHC50%).
- Utilized Cox proportional hazards analysis and Kaplan-Meier curves to analyze time to tumor progression.
Main Results:
- TERT mutations occurred in 47% and p53 mutations in 30% of patients.
- TERT mutations were more frequent in p53 mutation-positive cases (P=0.009).
- In TERT-negative tumors, p53 mutations correlated with shorter progression time (P=0.03); in TERT-positive tumors, p53 IHC50% positivity indicated longer progression time.
Conclusions:
- The combined TERT and p53 mutations are linked to tumor progression in T1 UBC.
- TERT promoter mutations might confer a protective effect against p53-driven tumor progression, requiring further investigation.
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