Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Steel Manufacturing

Steel Manufacturing

Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mitochondrial Dysfunction in Glycogen Storage Disorders (GSDs).

Biomolecules·2024

Same author

The Autophagic Activator GHF-201 Can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis.

Biomolecules·2024

Same author

A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies.

International journal of molecular sciences·2024

Same author

Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism.

EMBO molecular medicine·2024

Same author

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver-Serum-Brain Response.

Cells·2023

Same author

Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration.

Cells·2022

Search research articles

Related Experiment Video

Updated: Nov 4, 2025

Indirect Fabrication of Lattice Metals with Thin Sections Using Centrifugal Casting

Indirect Fabrication of Lattice Metals with Thin Sections Using Centrifugal Casting

Published on: May 14, 2016

Casting iron into the cell fate mold.

¹Department of Neurology, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel.

The Biochemical Journal

|May 24, 2021

Summary

Iron deficiency in yeast triggers autophagy and extends lifespan by influencing iron metabolism and cellular energy status. This links iron uptake to respiration during glucose depletion, impacting longevity.

Area of Science:

Cellular metabolism
Molecular biology
Aging research

Background:

Autophagy is a cellular process linked to longevity.
Nutrient availability significantly impacts cellular functions and lifespan.
Iron metabolism plays a critical role in cellular health and energy production.

Purpose of the Study:

To discuss the role of iron metabolism in autophagy-mediated life extension in Saccharomyces cerevisiae.
To explore the connection between iron availability, cellular energy status, and lifespan.
To highlight the interplay between glucose and iron metabolism during the diauxic shift.

Main Methods:

Commentary on existing research findings.
Analysis of the roles of TORC2 activator Ypk1p and iron regulator Aft1p.

More Related Videos

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

Casting Protocols for the Production of Open Cell Aluminum Foams by the Replication Technique and the Effect on Porosity

Casting Protocols for the Production of Open Cell Aluminum Foams by the Replication Technique and the Effect on Porosity

Published on: December 11, 2014

Related Experiment Videos

Last Updated: Nov 4, 2025

Indirect Fabrication of Lattice Metals with Thin Sections Using Centrifugal Casting

Indirect Fabrication of Lattice Metals with Thin Sections Using Centrifugal Casting

Published on: May 14, 2016

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

Casting Protocols for the Production of Open Cell Aluminum Foams by the Replication Technique and the Effect on Porosity

Casting Protocols for the Production of Open Cell Aluminum Foams by the Replication Technique and the Effect on Porosity

Published on: December 11, 2014

Discussion of cellular redox status sensing and energetic reporting.

Main Results:

Iron metabolism is crucial for autophagy-induced life extension, alongside central carbon metabolism.
The iron regulator Aft1p senses cellular redox status, reflecting energetic conditions.
Glucose and iron deficiencies are interconnected, with iron essential for respiration post-diauxic shift.

Conclusions:

Iron is a key nutrient influencing autophagy and lifespan extension in yeast.
Aft1p acts as a sensor linking iron availability to cellular energy and redox state.
Understanding these metabolic interplays offers insights into aging and cellular adaptation.