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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Disseminated Intravascular Coagulopathy in Critically Ill Patients in Amman, Jordan

Eman Mahmoud Qasim Emleek1, Amani Anwar Khalil2

  • 1Department of Bone Marrow Transplantation, The King Hussein Cancer Center (KHCC), 54658University of Jordan, Amman, Jordan.

Biological Research for Nursing
|May 25, 2021
PubMed

Insights

Disseminated intravascular coagulation (DIC) affects 4.45% of critically ill patients, with prevalence increasing from 2015-2017. The International Society of Thrombosis and Haemostasis (ISTH) overt-DIC score aids in identifying this condition in ICU patients.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Thrombosis and Hemostasis

Background:

  • Disseminated intravascular coagulation (DIC) is often under-recognized in critically ill patients.
  • The International Society of Thrombosis and Haemostasis (ISTH) developed a scoring system for DIC identification.
  • This study examined the period prevalence of ISTH-defined DIC in critically ill patients between 2015 and 2017.

Purpose of the Study:

  • To determine the period prevalence of disseminated intravascular coagulation (DIC) in critically ill patients.
  • To investigate the trend of DIC prevalence from 2015 to 2017.
  • To assess the utility of the ISTH overt-DIC score in critically ill populations.

Main Methods:

  • A multi-center, retrospective observational study.
  • Inclusion of all patients with a DIC code or medical diagnosis of DIC during admissions.
  • Classification of overt DIC based on ISTH DIC scores of ≥ 5.

Main Results:

  • A total of 220 patients were included, with a period prevalence of DIC at 4.45%.
  • Point prevalence increased from 3.49% in 2015 to 5.58% in 2017.
  • Overt DIC patients exhibited significantly lower hemoglobin and platelet counts, elevated creatinine, increased FDPs, and prolonged PT, PTT, and INR compared to non-overt DIC patients.

Conclusions:

  • The ISTH overt-DIC score is a valuable tool for identifying DIC in critically ill patients, irrespective of their underlying conditions.
  • The findings highlight the need for early prediction and identification of overt DIC using validated scoring systems upon ICU admission and during follow-up.
Abstract

Keywords:
DIC scoreISTHclinical factorsintensive care unit

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