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Updated: Nov 4, 2025

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Nonlinear relationship between visceral adiposity index and lung function: a population-based study.

Yide Wang1, Zheng Li2,3, Fengsen Li4,5

  • 1Department of Integrated Pulmonology, Fourth Clinical Medical College of Xinjiang Medical University, 116 Huanghe Road, Urumqi, Xinjiang, China.

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|May 25, 2021
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Summary

Visceral adipose index (VAI) shows an inverted U-shaped relationship with lung function in males, peaking between VAI 14-15. This association is stronger in men than women, highlighting sex differences in obesity and respiratory health.

Keywords:
Cross-sectional studiesLung functionObesityVisceral adiposity index

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Area of Science:

  • Pulmonology
  • Obesity Research
  • Public Health

Background:

  • Visceral fat is a key obesity indicator, with its link to lung disease under investigation.
  • The precise relationship between Visceral adipose index (VAI) and lung function remains unclear.
  • Understanding this connection is crucial for managing obesity-related respiratory conditions.

Purpose of the Study:

  • To investigate the association between Visceral adipose index (VAI) and lung function.
  • To explore potential sex-based differences in this relationship.

Main Methods:

  • Utilized data from 2367 participants (35-74 years) in the Northwest China Natural Population Cohort Study.
  • Collected questionnaires, physical examinations, visceral fat measurements, and lung function tests.
  • Employed piecewise linear spline models to analyze VAI and lung function associations.

Main Results:

  • A significant inverted U-shaped relationship between VAI and lung function was observed in the general and male populations.
  • In males, lung function initially increased with VAI up to 14, then decreased for VAI 15 and above.
  • No significant association was found between VAI and lung function in females.

Conclusions:

  • The relationship between VAI and lung function in males follows an inverted U-shaped curve with a turning point between VAI 14 and 15.
  • The association between visceral fat and lung function is more pronounced in males compared to females.
  • Findings suggest sex-specific implications of visceral adiposity for respiratory health.