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Updated: Nov 4, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

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Antibiotic Stewardship for the Neonatologist and Perinatologist

Sophie Katz1, Ritu Banerjee1, Hayden Schwenk2

  • 1Vanderbilt University Medical Center, 1161 21st Avenue, Nashville, TN 37232, USA.

Clinics in Perinatology
|May 25, 2021
PubMed

Insights

Antibiotic overuse is common in neonatal intensive care units. Implementing antibiotic stewardship programs can optimize antibiotic use and improve patient outcomes.

Area of Science:

  • Neonatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic use is prevalent in neonatal intensive care units (NICUs).
  • Current prescribing patterns indicate potential overuse and inappropriate use of antibiotics.
  • Key areas for intervention include sepsis, necrotizing enterocolitis, and perioperative prophylaxis.

Purpose of the Study:

  • To highlight targets for antibiotic stewardship in the NICU.
  • To explore the role of diagnostic stewardship in reducing unnecessary antibiotic prescribing.
  • To review strategies for improving antibiotic prescribing quality in neonates.

Main Methods:

  • Leveraging diagnostic stewardship principles, such as proper culture collection.
  • Implementing strategies like guideline development, prospective audit and feedback, and formulary restrictions.
  • Fostering multidisciplinary collaboration among neonatologists, surgeons, infectious diseases specialists, pharmacists, and nurses.

Main Results:

  • Antibiotic stewardship programs can effectively reduce inappropriate antibiotic use in the NICU.
  • Diagnostic stewardship can decrease the need for unnecessary antibiotic prescriptions.
  • Successful implementation relies on a collaborative, multidisciplinary approach.

Conclusions:

  • Antibiotic stewardship is crucial for optimizing antibiotic use in neonatal intensive care units.
  • Multidisciplinary collaboration is essential for successful antibiotic stewardship program implementation.
  • Targeted interventions can improve the quality and appropriateness of antibiotic prescribing in neonates.

Keywords:
AntibioticDiagnosticNeonatal intensive care unitSepsisStewardship

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