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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

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Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
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Related Experiment Video

Updated: Nov 4, 2025

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
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SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence.

Yuling Han1, Liuliu Yang1, Tae Wan Kim2,3

  • 1Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.

Research Square
|May 25, 2021
PubMed
Summary

Midbrain dopamine neurons are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, causing inflammation and senescence. FDA-approved drugs show potential for neuroprotection in COVID-19 patients.

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Related Experiment Videos

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Stem Cell Biology

Background:

  • COVID-19 frequently causes neurological symptoms, but the specific neural cells targeted by SARS-CoV-2 remain unclear.
  • Understanding neuronal susceptibility is crucial for addressing neurological complications in COVID-19 patients.

Conclusions:

  • hPSC-derived DA neurons provide a valuable model for studying SARS-CoV-2 neurotropism and developing neuroprotective strategies.
  • Findings suggest a need for long-term neurological monitoring in COVID-19 survivors due to observed neuronal responses.