A83586C, a new depsipeptide antibiotic
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T A Smitka1, J B Deeter, A H Hunt
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
The Journal of Antibiotics
|June 1, 1988
Abstract:
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.