Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pressure-flow behavior of pulmonary interstitium.

S J Lai-Fook1

  • 1Cardiovascular Research Institute, University of California, San Francisco.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1988
PubMed
Summary

Researchers developed a novel method to measure pulmonary interstitial pressure-flow dynamics. This study reveals a flow limitation phenomenon in lung interstitium, crucial for understanding fluid transport in pulmonary vessels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deformation of a flexible disk bonded to an elastic half space-application to the lung.

Journal of biomechanical engineering·2009
Same author

Effect of pancreatic and leukocyte elastase on hydraulic conductivity in lung interstitial segments.

Journal of applied physiology (Bethesda, Md. : 1985)·2004
Same author

Effect of concentration and hyaluronidase on restriction of hetastarch flux through lung interstitial segments.

Microvascular research·2003
Same author

Transport properties of alveolar epithelium measured by molecular hetastarch absorption in isolated rat lungs.

Journal of applied physiology (Bethesda, Md. : 1985)·2001
Same author

Effects of age on elastic moduli of human lungs.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Pleural tissue hyaluronan produced by postmortem ventilation in rabbits.

Lung·2000

Area of Science:

  • Pulmonary Physiology
  • Biomedical Engineering
  • Fluid Dynamics

Background:

  • Understanding the pressure-flow dynamics of the lung interstitium is critical for diagnosing and treating pulmonary edema and other fluid-related lung diseases.
  • Existing methods for measuring interstitial properties are limited, especially around large pulmonary vessels.

Purpose of the Study:

  • To present a novel method for measuring the pressure-flow behavior of the interstitium surrounding large pulmonary vessels.
  • To characterize the interstitial resistance and identify potential flow limitation phenomena.

Main Methods:

  • Isolated rabbit lungs were degassed and inflated with silicone rubber.
  • Lung tissue slabs containing large blood vessels were prepared.
  • Saline-filled chambers were used to measure interstitial flow under controlled pressures.

Main Results:

  • Interstitial flow decreased with reduced interstitial pressure, reaching a minimum at approximately -9 cmH2O.
  • An interstitial resistance of 1.31 +/- 1.03 cmH2O.h.cm-2 was calculated.
  • Flow limitation was demonstrated, with flow limiting at downstream pressures below -10 cmH2O.

Conclusions:

  • The developed method effectively measures pulmonary interstitial pressure-flow behavior.
  • A flow limitation phenomenon exists in the lung interstitium, influenced by interstitial pressure.
  • These findings provide insights into lung fluid dynamics and interstitial tissue properties.

Related Experiment Videos