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Updated: Nov 4, 2025

Knee Arthrocentesis in Adults
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EULAR recommendations for intra-articular therapies.

Jacqueline Uson1, Sebastián Cruz Rodriguez-García2, Raul Castellanos-Moreira3

  • 1Rheumatology Deptarment, Hospital Universitario Móstoles, Universidad Rey Juan Carlos, Madrid, Spain jusonjaeger@gmail.com.

Annals of the Rheumatic Diseases
|May 26, 2021
PubMed
Summary
This summary is machine-generated.

This study provides evidence-based recommendations for health professionals administering intra-articular therapies (IAT) for peripheral arthropathies. These guidelines aim to improve the uniformity and quality of care for patients receiving joint injections.

Keywords:
arthritishealth careosteoarthritisoutcome and process assessment

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Pharmacology

Background:

  • Intra-articular therapies (IAT) are widely used for peripheral arthropathies.
  • Standardized guidance for health professionals performing IAT is lacking.
  • A multidisciplinary task force was convened to address this gap.

Purpose of the Study:

  • To establish evidence-based recommendations for health professionals using IAT in adult patients with peripheral arthropathies.
  • To guide the practical application of IAT, covering pre-procedure, intra-procedure, and post-procedure aspects.
  • To enhance the quality and consistency of care in peripheral joint injections.

Main Methods:

  • A multidisciplinary international task force defined the scope and objectives.
  • Systematic literature reviews and surveys of healthcare providers and patients were conducted.
  • Recommendations were formulated through a three-round Delphi process with anonymous voting and assigned Oxford levels of evidence.

Main Results:

  • Five overarching principles and 11 specific recommendations were established.
  • Guidance covers patient information, procedural aspects, aseptic techniques, safety precautions for special populations, efficacy of repeated injections, local anesthetic use, and aftercare.
  • Recommendations address practical considerations for health professionals before, during, and after IAT.

Conclusions:

  • The study presents the first evidence and expert opinion-based recommendations for IAT in peripheral joints.
  • These recommendations aim to improve uniformity and quality of care.
  • The authors hope for integration into educational programs, patient association resources, and scientific society practices.