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Cyclodextrins in the antiviral therapy
László Jicsinszky1, Katia Martina1, Giancarlo Cravotto1
1Dept. of Drug Science and Technology, University of Turin, Via Giuria 9, 10125, Torino, Italy.
Journal of Drug Delivery Science and Technology
|May 26, 2021
Summary
Antiviral drug complexation with cyclodextrins can improve drug properties, but a universal solution is lacking. This review explores cyclodextrin derivatives for enhanced antiviral formulations and viral infection management.
Area of Science:
- Pharmaceutical Sciences
- Medicinal Chemistry
- Virology
Background:
- Antiviral drugs often face challenges with solubility and bioavailability due to their 3D structures.
- Current antiviral therapies lack universally effective solutions for diverse viral infections.
- Cyclodextrins are explored for their potential to modify drug properties.
Purpose of the Study:
- To summarize antiviral drug-cyclodextrin interactions and their impact on physicochemical properties.
- To review the potential of cyclodextrin derivatives in developing effective antiviral formulations.
- To discuss the application of cyclodextrins in preventing and treating viral infections, including SARS-CoV-2.
Main Methods:
- Literature review of antiviral drug-cyclodextrin complexation studies.
- Analysis of physicochemical and physiological property changes in virucides.
- Examination of existing and novel cyclodextrin derivatives for antiviral applications.
Main Results:
- Cyclodextrin complexation can improve solubility and bioavailability of antiviral molecules.
- Existing cyclodextrin derivatives are predominantly used in complexation experiments.
- Information on designing general antiviral medicines using cyclodextrins is limited, especially for SARS-CoV-2.
Conclusions:
- Cyclodextrin derivatives hold promise for enhancing antiviral drug delivery and efficacy.
- Further research is needed to design effective and broadly applicable cyclodextrin-based antiviral formulations.
- Novel cyclodextrin derivatives may offer new avenues for combating viral infections.
Keywords:
(2-hydroxy)propyl cyclodextrinCovid-19FavipiravirFenofibrateRemdesivirSulfobutyl cyclodextrinMore Related Videos
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