Single Nucleotide Polymorphisms as the Efficient Prognostic Markers in Breast Cancer

Area of Science:

• Oncology
• Pharmacogenomics
• Genetics

Background:

• Breast cancer (BC) is the most prevalent cancer in women globally.
• Both environmental and genetic factors influence BC progression.
• Genetic polymorphisms, specifically single nucleotide polymorphisms (SNPs), are recognized as significant risk factors for BC prognosis and therapeutic response.

Purpose of the Study:

• To comprehensively review single nucleotide polymorphisms (SNPs) associated with drug response in breast cancer (BC) patients worldwide.
• To categorize identified SNPs based on their gene functions to elucidate the molecular mechanisms of drug response in BC.

Main Methods:

• Systematic review of existing literature.
• Identification and summarization of single nucleotide polymorphisms (SNPs) linked to drug response in breast cancer patients.
• Categorization of SNPs according to associated gene functions.

Main Results:

• Numerous SNPs significantly associated with drug response in BC patients were identified globally.
• A majority of these SNPs were found within detoxifying enzyme genes.
• These genes represent key genetic factors influencing BC drug responses.

Conclusions:

• The identified SNPs, particularly those in detoxifying enzymes, are crucial genetic determinants of drug response in breast cancer.
• This comprehensive review provides a foundation for developing a prognostic panel of SNPs for breast cancer patients.
• Understanding these genetic factors can lead to more personalized and effective breast cancer treatment strategies.