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Short-term survival in extensive craniofacial resections
Ana Kober N Leite1, Gustavo Fernandes de Alvarenga1, Sérgio Gonçalves1
1Departamento de Cirurgia de Cabeca e Pescoco, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, BR.
Clinics (Sao Paulo, Brazil)
|May 26, 2021
Summary
Craniofacial resection (CFR) for tumors with cranial extension carries risks. Intracranial tumor extension and postoperative neurological issues significantly increase perioperative mortality risk in these extensive surgeries.
Area of Science:
- Oncology
- Neurosurgery
- Surgical Pathology
Background:
- Craniofacial resection (CFR) is a complex procedure for craniofacial tumors.
- While oncologically effective, CFRs are associated with significant perioperative risks.
Purpose of the Study:
- To identify risk factors for perioperative mortality following open craniofacial resection.
- Focus on deaths occurring during the initial hospitalization.
Main Methods:
- Retrospective analysis of 102 patients undergoing CFR from May 2009 to December 2018.
- Data collected from medical records at a tertiary oncology hospital.
Main Results:
- The majority of patients were male (72.5%), with a mean age of 61.
- Skin malignancies, primarily squamous cell carcinoma, comprised 63.4% of tumors.
- Independent risk factors for perioperative death included intracranial tumor extension (HR=4.56) and postoperative neurological dysfunction (HR=10.9).
Conclusions:
- Tumor extension into the cranium is a significant predictor of perioperative death after CFR.
- Postoperative neurological complications also independently increase mortality risk.
