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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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[Sleep-wake cycle regularity and cardiometabolic indicators].

M V Bochkarev1, L S Korostovtseva1, A B Tataraidze2

  • 1Almazov National Medical Research Center, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|May 26, 2021
PubMed
Summary

Sleep-wake rhythm significantly impacts cardiometabolic health. Stable sleep patterns and higher daytime activity are linked to better cardiovascular health indicators.

Keywords:
actigraphyactivitycardiovascular systemnonparametric analysissleepsleep-wakefulness rhythm

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Area of Science:

  • Chronobiology
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Sleep-wake rhythm disorders are increasingly recognized as potential contributors to cardiometabolic diseases.
  • Understanding the specific associations between sleep patterns and cardiometabolic parameters is crucial for public health.

Purpose of the Study:

  • To investigate the relationship between sleep-wake rhythm characteristics and various cardiometabolic health indicators.
  • To determine if sleep quality, stability, and activity patterns influence metabolic and cardiovascular markers.

Main Methods:

  • 103 adults (25-64 years) participated in a 7-day actigraphy study using Actigraph Actilife GT3X+.
  • Actigraphy data (sleep, physical activity) were analyzed using nonparametric indicators (e.g., stability, L5, M10).
  • Anthropometric, blood pressure, and laboratory parameters (e.g., glucose, lipids, CRP) were assessed.

Main Results:

  • Higher night activity correlated with improved sleep effectiveness and wake after sleep onset.
  • Stable sleep patterns were associated with favorable outcomes: more steps, lower weight, reduced waist circumference, and lower diastolic blood pressure, creatinine, and insulin.
  • Increased sleep fragmentation linked to elevated C-reactive protein (CRP) and sedentary time.
  • Greater activity contrast (day vs. night) correlated with lower waist circumference, hip circumference, body mass index (BMI), CRP, and insulin.

Conclusions:

  • Sleep-wake rhythm and quality are significant determinants of cardiometabolic health.
  • Stable sleep patterns, characterized by higher daytime activity and lower nighttime activity, are associated with a healthier cardiovascular system.