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Updated: Nov 4, 2025

08:26
Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
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Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus
Alexander J Ehrenberg1,2, Erica A Moehle1,2, Cara E Brook1,2
1University of California, Berkeley, California, United States of America.
Plos One
|May 26, 2021
Summary
University of California, Berkeley
Area of Science:
- Public Health
- Infectious Disease Surveillance
- Epidemiology
Background:
- Surveillance testing for SARS-CoV-2 is crucial for preventing outbreaks on college campuses.
- Early pandemic challenges required adaptable testing strategies.
Purpose of the Study:
- To describe the implementation and outcomes of a voluntary saliva testing program at UC Berkeley in 2020.
- To evaluate the program's effectiveness in routine, robust SARS-CoV-2 surveillance.
- To identify strategies for encouraging participation and fostering civic responsibility.
Main Methods:
- A voluntary saliva testing program was administered as a research study.
- The program allowed for ongoing assay optimization alongside surveillance.
- Participant experiences were evaluated alongside testing protocol results.
Main Results:
- The program provided routine and robust SARS-CoV-2 testing for the campus community.
- The study identified strategies to encourage participation in surveillance testing.
- The initiative contributed to outbreak prevention efforts.
Conclusions:
- Voluntary saliva testing can be an effective tool for SARS-CoV-2 outbreak prevention in university settings.
- Integrating research and clinical implementation facilitated rapid deployment and optimization.
- Strategies promoting participation are key to successful campus-wide surveillance.
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