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Lemierre's Syndrome Due to the Zoonotic Anaerobe Bacteroides pyogenes: Case Report and Literature Review

Kathryn P Goggin1, Nicholas Beckmann2, Kristen Bettin3

  • 1Department of Pediatrics, Division of Infectious Diseases, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Journal of the Pediatric Infectious Diseases Society
|May 26, 2021
PubMed

Insights

Fusobacterium necrophorum causes mastoiditis, but other anaerobes like Bacteroides pyogenes can cause severe infections. 16S sequencing identified this novel pathogen in a patient with severe sequelae.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genomics

Background:

  • Fusobacterium necrophorum is a known cause of acute mastoiditis in children.
  • Anaerobic bacterial infections can lead to severe complications such as sepsis and thrombophlebitis.

Observation:

  • A patient presented with severe sequelae, including intracranial and extracranial suppurative thrombophlebitis and sepsis.
  • Initial exposure history was unremarkable.

Findings:

  • 16S next-generation sequencing of a surgical specimen identified a novel pathogen, Bacteroides pyogenes.
  • This finding highlights the importance of advanced sequencing in identifying causative agents.

Implications:

  • Bacteroides pyogenes should be considered in the differential diagnosis of severe anaerobic infections.
  • Advances in genomic sequencing are crucial for pathogen discovery and understanding complex infections.
Keywords:
Bacteroides pyogenesPrevotellaLemierre’s syndromechildcholesteatoma

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