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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
The World Heart Federation Global Study on COVID-19 and Cardiovascular Disease
Karen Sliwa1,2, Kavita Singh3, Lana Raspail4
1Division of Cardiology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, Cape Town, ZA.
Insights
This study investigates cardiovascular manifestations and risk factors in hospitalized COVID-19 patients, particularly from low- and middle-income countries. Findings will inform interventions for severe disease and improve outcomes for patients with cardiovascular involvement.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, poses a global health challenge.
- Rapid transmission is driven by asymptomatic spread and high infectivity.
- Limited data exists on cardiovascular manifestations in hospitalized COVID-19 patients, especially from low- and middle-income countries.
Purpose of the Study:
- To describe cardiovascular manifestations in patients hospitalized with COVID-19.
- To identify cardiovascular risk factors associated with COVID-19 hospitalization.
- To provide crucial data from diverse global settings, including underrepresented regions.
Main Methods:
- An observational cohort study involving 5000 adult COVID-19 patients.
- Recruitment from hospitals in low-, middle-, and high-income countries.
- Follow-up until 30 days post-admission, recording outcomes at discharge.
Main Results:
- Data collection on ICU admission, ventilation, mortality, major adverse cardiovascular events, neurological, renal, and pulmonary outcomes.
- Analysis of cardiovascular manifestations and associated risk factors.
- Focus on outcomes in diverse patient populations.
Conclusions:
- The study will offer insights into risk factors for severe COVID-19 disease.
- It will detail the clinical presentation and outcomes of cardiovascular manifestations.
- Findings will be particularly valuable for understanding COVID-19's impact in low- and middle-income countries.
Background:
The emergence of novel coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has presented an unprecedented global challenge for the healthcare community. The ability of SARS-CoV-2 to get transmitted during the asymptomatic phase, and its high infectivity have led to the rapid transmission of COVID-19 beyond geographic regions facilitated by international travel, leading to a pandemic. To guide effective control and interventions, primary data is required urgently, globally, including from low- and middle-income countries where documentation of cardiovascular manifestations and risk factors in people hospitalized with COVID-19 is limited.
Objectives:
This study aims to describe the cardiovascular manifestations and cardiovascular risk factors in patients hospitalized with COVID-19.
Methods:
We propose to conduct an observational cohort study involving 5000 patients recruited from hospitals in low-, middle- and high-income countries. Eligible adult COVID-19 patients will be recruited from the participating hospitals and followed-up until 30 days post admission. The outcomes will be reported at discharge and includes the need of ICU admission, need of ventilator, death (with cause), major adverse cardiovascular events, neurological outcomes, acute renal failure, and pulmonary outcomes.
Conclusion:
Given the enormous burden posed by COVID-19 and the associated severe prognostic implication of CVD involvement, this study will provide useful insights on the risk factors for severe disease, clinical presentation, and outcomes of various cardiovascular manifestations in COVID-19 patients particularly from low and middle income countries from where the data remain scant.
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