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An update on the diagnostic biomarkers for asthma
Rashmi Pandey1, Ved Parkash1, Surya Kant2
1Department of Pulmonary and Critical Care Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of Family Medicine and Primary Care
|May 27, 2021
Summary
This review explores biomarkers for diagnosing asthma, a respiratory condition affecting millions. It covers current diagnostic methods and emerging molecular indicators for better asthma detection.
Area of Science:
- Pulmonology
- Immunology
- Biochemistry
Background:
- Asthma is a prevalent respiratory disorder affecting approximately 339 million individuals annually.
- Current asthma diagnosis relies on symptom assessment (wheezing, shortness of breath, cough) and spirometry with bronchodilator response.
- Asthma pathophysiology involves immune system components, particularly cytokines, highlighting the need for precise diagnostic tools.
Purpose of the Study:
- To review existing and potential molecular biomarkers for improved asthma diagnosis.
- To explore the role of cytokines in asthma and their diagnostic utility.
- To provide an overview of current diagnostic approaches and future directions in asthma biomarker discovery.
Main Methods:
- Literature review of studies on asthma diagnosis and biomarkers.
- Analysis of the role of immune system molecules, including cytokines, in asthma.
- Examination of diagnostic criteria and testing methodologies for asthma.
Main Results:
- Current diagnostic methods for asthma include symptom evaluation and spirometry.
- Cytokines and other immune molecules are implicated in asthma pathophysiology.
- Various molecules show potential as biomarkers for asthma diagnosis, complementing existing methods.
Conclusions:
- Accurate asthma diagnosis is crucial for effective management.
- Biomarkers, especially those related to immune responses like cytokines, offer promise for enhancing asthma diagnostic accuracy.
- Further research into novel biomarkers can lead to earlier and more precise asthma detection.
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