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Updated: Nov 4, 2025

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
Published on: December 16, 2022
Fetal Unguarded Mitral Valve Orifice, Aortic Atresia, and Severe Left Heart Enlargement
Lisa W Howley1,2, Janette Strasburger3, Joseph J Maleszewski4
1Division of Cardiology, Department of Pediatrics, The Children's Heart Clinic, Children's Minnesota, Minneapolis, Minnesota, USA.
Abstract:
Unguarded mitral valve orifice is a rare disease with only 7 described cases in the literature. We describe the first known case of unguarded mitral valve orifice with normal segmental cardiac anatomy, severe left ventricular dilatation and dysfunction, aortic atresia, and atrial flutter. (Level of Difficulty: Advanced.).
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