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Published on: May 18, 2018
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[Reed nevus and cutaneous melanoma in children: an immunohistochemical study]
G M Volgareva1, L E Zavalishina2, O A Kuznetsova2
1Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Arkhiv Patologii
|May 27, 2021
Summary
Diagnosing pediatric Reed nevus versus melanoma is challenging. Immunohistochemistry for cyclin D1, p16INK4a, and HLA class I antigens shows promise in differentiating these skin neoplasms.
Area of Science:
- Dermatopathology
- Oncology
- Immunohistochemistry
Background:
- Differentiating Reed nevus from cutaneous melanoma in pediatric patients presents diagnostic challenges.
- Classical histological examination may be insufficient for accurate diagnosis of pigmented skin neoplasms in children.
Observation:
- This study evaluated cyclin D1, p16INK4a, and HLA class I antigens for differential diagnosis.
- Immunohistochemical staining was performed on pediatric Reed nevus and melanoma samples.
Findings:
- Cyclin D1 nuclear expression was higher in melanoma than in nevus.
- p16INK4a nuclear expression was significantly reduced in melanoma compared to nevus.
- HLA class I antigens were absent in melanoma cells but present on nevus cells, potentially aiding immune evasion.
Implications:
- Immunohistochemistry for these markers offers a promising adjunct for diagnosing pediatric Reed nevus and melanoma.
- Accurate diagnosis is crucial for appropriate management of pigmented skin lesions in children and adolescents.
