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Updated: Nov 4, 2025
08:03
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
9.2K
Selenium-engineered covalent organic frameworks for high-efficiency and long-acting cancer therapy
Xiuyan Wan1, Tong Wu1, Liqun Song1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn tangb@sdnu.edu.cn.
Chemical Communications (Cambridge, England)
|May 27, 2021
Summary
This study introduces a novel porphyrin-based covalent organic framework (COF) for decorating selenium nanoparticles (Se NPs). Combining Se NP-mediated therapy (SeT) with photodynamic therapy (PDT) enhances anticancer effects.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Photodynamic therapy (PDT) shows promise for cancer treatment but faces limitations in efficacy.
- Developing novel drug delivery systems and therapeutic strategies is crucial for overcoming these limitations.
Purpose of the Study:
- To synthesize a porphyrin-containing covalent organic framework (COF) as a platform for selenium nanoparticle (Se NP) synthesis.
- To evaluate the combined therapeutic effect of Se NP-mediated therapy (SeT) and PDT against cancer.
Main Methods:
- A porphyrin-based COF was synthesized and used as a substrate for in situ reduction to decorate Se NPs.
- The synthesized Se NP-decorated COF was tested for its combined anticancer efficacy using SeT and PDT.
Main Results:
- Successful synthesis of a porphyrin-containing COF decorated with Se NPs.
- The combined SeT and PDT approach demonstrated enhanced anticancer effects compared to individual therapies.
Conclusions:
- Porphyrin-based COFs can serve as effective platforms for Se NP synthesis.
- The synergistic effect of SeT and PDT offers a promising strategy to improve cancer treatment outcomes.
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