Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives

In our previous studies, a kind of novel benzenesulfonamides was found to be a candidate insecticidal compounds. It was shown that propargyloxy and sulfonamide groups are pharmacodynamic groups. One hundred and twenty-six (126) naphthalenesulfonamides derivatives with propargyloxy functionality were designed and synthesized, and their insecticidal activities were determined. Some of them showed outstanding activity, with LC₅₀ values as low as 0.202 mg ml^-1, much lower than that of the positive control celangulin V (23.9 mg ml^-1). In addition, the structure-activity relationships were discussed, and molecular docking was used to verify the binding mode of the compound and the target receptor.