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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Nov 4, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous and Mucocutaneous Leishmaniasis.

I Abadías-Granado1, A Diago1, P A Cerro1

  • 1Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Actas Dermo-Sifiliograficas
|May 28, 2021
PubMed
Summary

Leishmaniasis is a chronic parasitic disease affecting millions globally. Diagnosis involves identifying Leishmania parasites, with treatment challenges, especially for cutaneous forms, exacerbated by immune deficiencies.

Keywords:
Clinical manifestationsCutaneous leishmaniasisDiagnosisDiagnósticoLeishmaniasis cutáneaLeishmaniasis mucocutáneaManifestaciones clínicasMucocutaneous leishmaniasisTratamientoTreatment

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Area of Science:

  • Parasitology
  • Infectious Diseases
  • Global Health

Background:

  • Leishmaniasis is a chronic disease caused by flagellate protozoa of the genus Leishmania.
  • It is a global health concern, prevalent in South America, the Mediterranean, Asia, and Africa.
  • The disease manifests in three main forms: cutaneous, mucocutaneous, and visceral (kala-azar).

Purpose of the Study:

  • To provide an overview of leishmaniasis, including its types, diagnosis, and treatment.
  • To highlight the impact of acquired immune deficiency on leishmaniasis presentation and management.
  • To underscore the need for improved evidence-based treatment options for cutaneous leishmaniasis.

Main Methods:

  • Diagnosis relies on identifying Leishmania amastigotes in clinical specimens.
  • Methods include direct microscopic examination and molecular analysis.
  • The abstract discusses changes in disease presentation and management.

Main Results:

  • Cutaneous leishmaniasis is the most common form, while visceral leishmaniasis is the most severe.
  • Evidence supporting treatments for cutaneous leishmaniasis is currently weak.
  • Acquired immune deficiency (e.g., from HIV or TNF inhibitors) alters disease presentation and management.

Conclusions:

  • Leishmaniasis diagnosis is established through direct microscopic or molecular identification of parasites.
  • Treatment options for cutaneous leishmaniasis require further evidence-based support.
  • The management of leishmaniasis is evolving due to increased immunocompromised patient populations.