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Management of Dermatological Adverse Events Associated With MEK Inhibitors

C Prat1, Laura Berbegal de Gracia2, J Bernabeu-Wittel3

  • 1Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

Actas Dermo-Sifiliograficas
|April 18, 2026
PubMed

Insights

MEK inhibitors (MEKi) manage tumors but cause skin issues. This consensus offers practical advice for preventing and treating these common MEKi dermatologic toxicities to improve patient quality of life.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • MEK inhibitors (MEKi) are effective cancer treatments.
  • Dermatologic adverse effects are common with MEKi therapy.
  • These toxicities can impact quality of life and treatment adherence.

Purpose of the Study:

  • To review evidence on MEKi-associated cutaneous toxicities.
  • To provide practical recommendations for prevention and management.
  • To emphasize multidisciplinary collaboration for optimal patient care.

Main Methods:

  • Expert consensus review of existing evidence.
  • Identification of common dermatologic toxicities.
  • Development of management strategies.

Main Results:

  • Common toxicities include acneiform rash, xerosis, paronychia, and mucositis.
  • Most reactions are mild to moderate and manageable.
  • Preventive measures, topical/oral treatments, and patient education are effective.

Conclusions:

  • Effective management of MEKi-induced skin toxicities is achievable.
  • Multidisciplinary collaboration between dermatology and oncology is crucial.
  • Optimizing treatment outcomes and patient quality of life is possible.
Keywords:
BinimetinibCobimetinibDrug eruptionsMEK inhibitorsSelumetinibTrametinib

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