Arbutin attenuates nephrotoxicity induced by gentamicin
Elnaz Emadi1,2, Mahdi Pouramir3,2, Maryam Ghasemi-Kasman3
1Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Avicenna Journal of Phytomedicine
|May 28, 2021
Summary
Arbutin protects against gentamicin-induced kidney damage by reducing harmful oxidative stress markers. This study demonstrates arbutin
Area of Science:
- Pharmacology and Toxicology
- Biochemistry
- Nephrology
Background:
- Gentamicin (GM) is an antibiotic known to cause nephrotoxicity.
- Oxidative stress plays a significant role in GM-induced kidney damage.
- Arbutin is a compound with potential antioxidant properties.
Purpose of the Study:
- To investigate the protective effects of arbutin against gentamicin-induced nephrotoxicity in a rat model.
- To evaluate the impact of arbutin on oxidative stress markers and kidney function following gentamicin exposure.
Main Methods:
- Adult male Wistar rats were divided into five groups: control, GM-only, and GM with three doses of arbutin (25, 50, 75 mg/kg).
- Serum and kidney tissue levels of creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARS), ferric reducing antioxidant power (FRAP), and 8-hydroxyguanosine were measured.
- Histological evaluation of kidney tissue was performed to assess structural damage.
Main Results:
- Gentamicin administration significantly increased serum urea, creatinine, 8-hydroxyguanosine, TBARS, and carbonyl levels, indicating nephrotoxicity and oxidative stress.
- Arbutin treatment dose-dependently attenuated the increases in serum creatinine, urea, 8-hydroxyguanosine, and TBARS.
- Arbutin administration also reduced carbonyl levels in serum and renal tissue and increased FRAP levels, suggesting antioxidant activity and protection against kidney damage.
Conclusions:
- Arbutin exhibits significant protective effects against gentamicin-induced nephrotoxicity.
- The renoprotective mechanism of arbutin appears to be mediated through its potent free radical-scavenging and antioxidant activities.
- Arbutin represents a potential therapeutic agent for preventing or treating antibiotic-induced kidney injury.
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