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MicroRNAs: Key Regulators in Lung Cancer
Younes El Founini1, Imane Chaoui1, Hind Dehbi2
1Unit of Biology and Medical Research, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Microrna (Shariqah, United Arab Emirates)
|May 28, 2021
Summary
MicroRNAs (miRNAs) are key regulators in lung cancer, influencing malignancy and serving as potential noninvasive biomarkers. This review highlights their roles and clinical applications for targeted lung cancer therapies.
Area of Science:
- Molecular Biology
- Genomics
- Oncology
Background:
- Noncoding RNAs, particularly microRNAs (miRNAs), are crucial gene expression regulators.
- Dysregulated miRNAs are implicated in the development and progression of human cancers, including lung cancer.
- miRNAs impact lung cancer malignancy, affecting proliferation, survival, migration, invasion, angiogenesis, and therapy resistance.
Purpose of the Study:
- To review the deregulation and mechanisms of microRNAs in lung cancer.
- To highlight the functions and clinical applications of miRNAs in lung cancer management.
- To explore the potential of extracellular miRNAs as diagnostic and prognostic biomarkers.
Main Methods:
- Literature review focusing on recent publications.
- Analysis of miRNA deregulation and mechanisms in lung cancer.
- Examination of clinical applications and biomarker potential.
Main Results:
- miRNAs act as oncogenes or tumor suppressors in lung cancer.
- Extracellular miRNAs in body fluids show promise as noninvasive biomarkers.
- miRNA expression is often associated with clinical parameters in lung cancer patients.
Conclusions:
- MicroRNAs play multifaceted roles in lung cancer progression and malignancy.
- Extracellular miRNAs offer potential for noninvasive diagnosis and prognosis of lung cancer.
- Targeted therapies based on miRNA functions could improve lung cancer management.
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