Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 4, 2025

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
09:08

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

16.1K

Mouse Intensive Care Unit (MICU).

Tamara Merz1, Sandra Kress1, Michael Gröger1

  • 1Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, Ulm, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|May 28, 2021
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine.

Intensive care medicine experimental·2026
Same author

Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs".

Biomedicines·2026
Same author

Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial.

Annals of intensive care·2026
Same author

Vascular permeability and loss of glycocalix in sepsis: the role of fluid resuscitation.

Intensive care medicine·2026
Same author

Cold-induced stress responses during a self-rescue exercise from accidental immersion in ice water in military personnel.

Frontiers in physiology·2025
Same author

Mitochondrial respiratory activity and DNA damage in peripheral blood mononuclear cells in borderline personality disorder.

Psychological medicine·2025
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Translational research in sepsis faces challenges due to unrealistic preclinical models. The mouse intensive care unit (MICU) simulates clinical intensive care, improving sepsis model translatability.

Area of Science:

  • Critical care medicine
  • Translational research
  • Sepsis research

Background:

  • Translating preclinical sepsis findings to clinical practice is difficult.
  • Preclinical models often lack the complexity of human sepsis patients, particularly regarding resuscitation and comorbidities.
  • Existing models do not adequately reflect intensive care unit (ICU) management.

Purpose of the Study:

  • To introduce the mouse intensive care unit (MICU) as a novel preclinical model for sepsis research.
  • To address the limitations of current preclinical sepsis models, specifically the lack of resuscitation.
  • To enhance the translational validity of sepsis research by incorporating clinical ICU procedures.

Main Methods:

  • Development of a mouse intensive care unit (MICU) that mimics clinical ICU settings.
Keywords:
Circulatory shockIntensive carePolytraumaPreclinical animal modelSepsisTranslational medicine

More Related Videos

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

624
The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

988

Related Experiment Videos

Last Updated: Nov 4, 2025

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
09:08

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

16.1K
Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

624
The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

988
  • Implementation of key ICU procedures: fluid resuscitation, lung-protective mechanical ventilation, and hemodynamic monitoring.
  • Tailoring interventions to organ- and function-specific targets in experimental animals.

    • Main Results:

    • The MICU provides a platform for "patient" management, allowing experimental animals a possibility of recovery.
    • This approach bridges the gap between simplified preclinical models and complex clinical realities.
    • The MICU facilitates the study of sepsis under conditions more relevant to human ICU patients.

    Conclusions:

    • The MICU represents a significant advancement in preclinical sepsis research methodology.
    • This model enhances the translatability of sepsis research by incorporating critical care interventions.
    • The MICU offers a more realistic platform for developing effective sepsis therapies.