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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

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The International Society for Stem Cell Research updated its guidelines to reflect stem cell science advances. These updated guidelines maintain core principles while addressing new ethical and clinical translation issues.

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Area of Science:

  • Stem Cell Research
  • Regenerative Medicine
  • Biomedical Ethics

Background:

  • The International Society for Stem Cell Research (ISSCR) last updated its guidelines in 2016.
  • Significant advancements in stem cell science and clinical applications have occurred since 2016.
  • New ethical, social, and policy issues have emerged alongside these scientific developments.

Purpose of the Study:

  • To present a summary of key updates and issues in the latest ISSCR Guidelines for Stem Cell Research and Clinical Translation.
  • To address the evolving landscape of stem cell science and its societal implications.
  • To provide an updated resource for researchers, clinicians, regulators, and the public.

Main Methods:

  • Review and synthesis of recent advancements in stem cell biology and therapeutic applications.
  • Analysis of emerging ethical, social, and regulatory challenges.
  • Incorporation of expert consensus and stakeholder input into revised guideline principles.

Main Results:

  • The updated ISSCR Guidelines encompass the latest scientific discoveries and clinical translation progress.
  • Key ethical considerations, including those related to novel stem cell applications and accessibility, are addressed.
  • The guidelines provide updated recommendations for responsible stem cell research and clinical practice.

Conclusions:

  • The revised ISSCR Guidelines serve as a crucial standard for the field, balancing scientific progress with ethical considerations.
  • These updated guidelines are essential for navigating the complexities of stem cell research and its translation to clinical practice.
  • The ISSCR remains committed to fostering responsible innovation in stem cell science for the benefit of society.