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Porcine germline genome engineering.

Luhan Yang1, George Church2, Hong-Ye Zhao3

  • 1Department of Research and Development, Qihan Bio Inc., Hangzhou, Zhejiang 311200, China; luhan.yang@qihanbio.com gchurch@genetics.med.harvard.edu.

Proceedings of the National Academy of Sciences of the United States of America
|May 29, 2021
PubMed
Summary
This summary is machine-generated.

Germline genome editing in pigs offers significant potential for agricultural and biomedical advancements. This review explores current techniques, applications, and challenges in mammalian germline editing, highlighting its clinical possibilities.

Keywords:
agriculturedisease modelgermline genome editingpigxenotransplantation

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Area of Science:

  • Genetics and Genomics
  • Animal Biotechnology
  • Reproductive Biology

Background:

  • Germline editing involves heritable genome modifications.
  • Pigs are extensively utilized in agricultural and biomedical research due to genome modification.
  • Previous studies have explored germline editing in various animal models.

Purpose of the Study:

  • To review methodologies, applications, and challenges of mammalian germline genome editing.
  • To focus on pigs as a model system for germline editing research.
  • To discuss the broader implications and clinical potential of animal germline editing.

Main Methods:

  • Review of existing literature on germline genome editing technologies.
  • Focus on pig models for genome modification.
  • Analysis of current applications and future prospects.

Main Results:

  • Germline editing technologies have been applied to diverse animal species.
  • Extensive modification of the pig genome using various technologies has been achieved.
  • The review synthesizes information on methodologies, applications, and challenges.

Conclusions:

  • Pigs serve as a valuable model for studying mammalian germline genome editing.
  • Germline editing in pigs has significant implications for agriculture and medicine.
  • Further research is needed to address challenges and explore clinical potential.