Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

565
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
565

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postconcussion physical activity frequency and plasma biomarker associations among adolescents.

Journal of neurosurgery. Pediatrics·2026
Same author

Concussion Symptom Resolution Expectations and Subsequent Development of Persisting Symptoms After Adolescent Concussion.

Journal of athletic training·2026
Same author

Sport versus Nonsport Injury Setting as a Moderator of Postconcussive Symptoms Following Pediatric Concussion: An Advancing Concussion Assessment in Pediatrics Study.

The Journal of pediatrics·2026
Same author

Evaluating Associations Between Postconcussion Physical Activity and Brain Neurometabolite Concentrations in the Posterior Cingulate Gyrus.

Journal of child neurology·2026
Same author

The Integrated Effect of Physical Activity and Sleep Problems on Concussion Symptom Resolution.

Journal of sport rehabilitation·2026
Same author

Performance validity tests in a large racially and linguistically diverse pediatric and young adult clinical sample: Investigations of the TOMM, MVP, and MSVT.

The Clinical neuropsychologist·2026
Same journal

Proximal Calf Muscle Cross-Sectional Area After Anterior Cruciate Ligament Reconstruction: A Longitudinal MRI Evaluation.

Journal of sport rehabilitation·2026
Same journal

We Thought You'd Never Ask: Insights From the Health of Elite Retired Australian Female Athletes Survey.

Journal of sport rehabilitation·2026
Same journal

Physical Factors Associated With Chronic Low Back Pain in Collegiate Baseball Players: A Cross-Sectional Study.

Journal of sport rehabilitation·2026
Same journal

Validity and Reliability of a Modified Seated Athletic Shoulder Test Using a Functional Electromechanical Dynamometer.

Journal of sport rehabilitation·2026
Same journal

Reliability of Inertial Sensors for Measuring Scapular Kinematics in Individuals With Shoulder Pain and Scapular Dyskinesis.

Journal of sport rehabilitation·2026
Same journal

Comment on: "Sequential Changes in Scapular Range of Motion After an Intervention Using the KOJI AWARENESS Original 'Wall Angel Slider' Exercise".

Journal of sport rehabilitation·2026
See all related articles

Related Experiment Video

Updated: Nov 4, 2025

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

649

The Nocebo Effect and Pediatric Concussion.

Michael W Kirkwood, David R Howell, Brian L Brooks

    Journal of Sport Rehabilitation
    |May 29, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Nocebo effects, or harm from negative expectations, can worsen pediatric concussion recovery. This review offers clinical strategies to mitigate these nocebo effects for better patient outcomes.

    Keywords:
    adolescentsmild traumatic brain injuryplacebo effectrehabilitationsymptomatology

    More Related Videos

    A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
    11:32

    A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

    Published on: December 8, 2014

    13.0K
    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
    07:02

    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

    Published on: January 12, 2011

    16.0K

    Related Experiment Videos

    Last Updated: Nov 4, 2025

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
    07:01

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

    Published on: February 7, 2025

    649
    A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
    11:32

    A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

    Published on: December 8, 2014

    13.0K
    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
    07:02

    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

    Published on: January 12, 2011

    16.0K

    Area of Science:

    • Pediatric Medicine
    • Neuroscience
    • Psychology

    Background:

    • Placebo effects are recognized in medicine, but nocebo effects are less understood.
    • Nocebo effects stem from negative expectations influencing health outcomes.
    • These effects can complicate the recovery process for pediatric concussion patients.

    Purpose of the Study:

    • To explore the occurrence and impact of nocebo effects in pediatric concussion.
    • To provide actionable recommendations for clinicians to prevent or reduce nocebo effects.
    • To enhance recovery trajectories for children experiencing concussion.

    Main Methods:

    • Review of existing literature on nocebo effects in clinical settings.
    • Analysis of how negative expectations may manifest in pediatric concussion.
    • Development of evidence-based strategies for clinical practice.

    Main Results:

    • Nocebo effects can exacerbate pediatric concussion symptoms and prolong recovery.
    • Specific clinician communication strategies can influence patient expectations.
    • Awareness of biases and careful messaging are crucial for managing nocebo responses.

    Conclusions:

    • Clinicians play a vital role in managing nocebo effects in pediatric concussion care.
    • Implementing suggested strategies can mitigate negative impacts and improve patient outcomes.
    • Further attention to nocebo effects is warranted in pediatric neurological care.