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Updated: Nov 4, 2025

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Bubble Forming Films for Spatial Selective Cell Killing.

Dawei Hua1,2, Aranit Harizaj2, Mike Wels2

  • 1Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing, 210037, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|May 29, 2021
PubMed
Summary
This summary is machine-generated.

New bubble-films with embedded iron oxide nanoparticles offer precise, localized cell killing using laser-induced vapor bubbles. This method shows promise for safe nanosurgery, particularly in ophthalmology for superficial tumor removal.

Keywords:
corneananosurgeryphotoablationphotodynamic therapysingle cell killing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Photodynamic and photothermal therapies are used for cell killing but risk damaging surrounding tissues due to uncontrolled heat dissipation.
  • Current methods for localized cell ablation lack precise control, potentially leading to collateral damage in sensitive areas like the eye.

Purpose of the Study:

  • To develop a novel strategy for precise, localized cell killing at tissue surfaces using polymeric films.
  • To investigate the efficacy of these "bubble-films" for applications in nanosurgery, specifically targeting superficial tumors.

Main Methods:

  • Polymeric films embedded with iron oxide nanoparticles (photosensitizers) were fabricated.
  • Irradiation with pulsed laser light was used to generate water vapor bubbles on the film surface.
  • The mechanical forces from bubble collapse were analyzed for cell-killing effects.
  • Bubble-film application on corneal tissue was tested for selective cell ablation.

Main Results:

  • Laser irradiation of bubble-films generated vapor bubbles that killed nearby cells via mechanical forces upon collapse.
  • Localized irradiation enabled spatial-selective single-cell killing.
  • Bubble-films successfully demonstrated spatial and selective killing of corneal cells when applied to the cornea.

Conclusions:

  • Bubble-films provide a method for controlled, localized cell ablation with minimal risk of spreading due to embedded photosensitizers and film removability.
  • The low laser energy required and the ability to precisely target cells make bubble-films a promising tool for safe superficial tumor resection, especially in ophthalmology.