Related Experiment Video
Updated: Nov 4, 2025
13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
28.1K
Small airway dysfunction and poor asthma control: a dangerous liaison
Marcello Cottini1, Anita Licini1, Carlo Lombardi2
1Allergy and Pneumology Outpatient Clinic, Bergamo, Italy.
Clinical and Molecular Allergy : CMA
|May 30, 2021
Summary
Small airway dysfunction (SAD) significantly impacts asthma control, despite treatment guidelines. Impulse oscillometry (IOS) shows promise in assessing SAD and guiding therapy for better patient outcomes.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Research
Background:
- Asthma affects 339 million globally, with a primary treatment goal of clinical control.
- Despite evidence, many asthma patients experience poor control in real-world settings.
- Peripheral small airway involvement is increasingly recognized as a factor in persistent asthma.
Purpose of the Study:
- To review current literature on small airway dysfunction (SAD) in asthma.
- To examine the influence of SAD on asthma control.
- To highlight recent evidence and the role of impulse oscillometry (IOS).
Main Methods:
- Literature review focusing on small airway dysfunction and asthma control.
- Analysis of studies investigating the impact of small airway inflammation.
- Evaluation of impulse oscillometry (IOS) for assessing small airways.
Main Results:
- Persistent inflammation in small airways contributes to small airway dysfunction (SAD).
- SAD is strongly associated with poorer asthma control.
- Impulse oscillometry (IOS) appears more sensitive than spirometry in detecting small airway abnormalities.
Conclusions:
- Small airway dysfunction is a critical factor in achieving asthma control.
- IOS may be a valuable tool for characterizing SAD and personalizing asthma treatment.
- Further research into SAD and IOS can improve management strategies for poorly controlled asthma.
More Related Videos
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
3.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.5K
01:20Asthma: Pathogenesis and Management
901
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
901
01:24Asthma-III: Symptoms and Complications
2.8K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.8K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.5K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.5K
01:29Asthma-I: Introduction
2.9K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.9K
01:19Factors Affecting Pulmonary Ventilation
2.0K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.0K