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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Pathophysiology of Heart Failure with Preserved Ejection Fraction
Jong-Chan Youn1, Yuran Ahn1, Hae Ok Jung1
1Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Heart Failure Clinics
|May 30, 2021
Summary
Heart failure with preserved ejection fraction (HFpEF) is a growing public health issue. This syndrome, characterized by diastolic dysfunction, leads to increased left ventricular filling pressures and dyspnea, with limited treatment options.
Area of Science:
- Cardiology
- Internal Medicine
- Public Health
Background:
- Heart failure with preserved ejection fraction (HFpEF) affects half of all heart failure patients.
- HFpEF prevalence is increasing, associated with significant morbidity and mortality.
- Effective treatments for HFpEF remain limited.
Purpose of the Study:
- To describe the current understanding of HFpEF pathophysiology.
- To highlight the role of diastolic dysfunction in HFpEF.
- To underscore the clinical impact of increased left ventricular filling pressures.
Main Methods:
- Review of current literature on HFpEF.
- Analysis of the interplay between cardiac and extracardiac factors.
- Focus on diastolic dysfunction mechanisms.
Main Results:
- HFpEF is a heterogeneous syndrome.
- Diastolic dysfunction is a key pathophysiological feature.
- Impaired relaxation and increased chamber stiffness elevate filling pressures, causing dyspnea.
Conclusions:
- Understanding HFpEF heterogeneity is crucial.
- Diastolic dysfunction drives HFpEF symptoms.
- Further research is needed for effective HFpEF treatments.
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