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Updated: Nov 4, 2025
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Valvular Disease and Heart Failure with Preserved Ejection Fraction
Yiting Fan1, Alex Pui-Wai Lee2
1Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xu Hui District, Shanghai, China.
Heart Failure Clinics
|May 30, 2021
Summary
Heart failure with preserved ejection fraction (HFpEF) involves elevated left ventricular filling pressures. Early intervention for secondary HFpEF improves outcomes, while primary HFpEF requires further study regarding valve regurgitation.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) is characterized by elevated left ventricular filling pressures.
- HFpEF can stem from primary diastolic dysfunction or secondary underlying causes.
Purpose of the Study:
- To differentiate the management and prognosis of primary versus secondary HFpEF.
- To highlight the role of atrioventricular valve regurgitation in primary HFpEF.
Main Methods:
- Review of clinical syndromes and diagnostic criteria for HFpEF.
- Analysis of outcomes based on underlying causes and presence of valvular disease.
Main Results:
- Early intervention in secondary HFpEF, particularly valvular heart disease, improves symptoms and survival.
- Secondary atrioventricular valve regurgitation is increasingly recognized in primary HFpEF with significant prognostic implications.
Conclusions:
- Distinguishing between primary and secondary HFpEF is crucial for effective management.
- Further research is needed to understand the mechanisms and therapeutic potential of addressing valvular regurgitation in primary HFpEF.
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