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Clinical Phenogroups in Heart Failure with Preserved Ejection Fraction.
Hidemi Sorimachi1, Kazunori Omote1, Barry A Borlaug1
1Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Heart Failure Clinics
|May 30, 2021
Summary
Effective treatments for heart failure with preserved ejection fraction (HFpEF) remain elusive due to its complex and varied patient phenotypes. This review explores recognized HFpEF phenotypes and potential therapeutic strategies for improved patient outcomes.
Area of Science:
- Cardiology
- Internal Medicine
- Translational Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) constitutes over half of all heart failure cases.
- Current treatment strategies for HFpEF lack efficacy due to the condition's heterogeneity.
- A need exists for precise patient categorization into phenogroups for targeted therapies.
Purpose of the Study:
- To review and describe the currently recognized phenotypes of heart failure with preserved ejection fraction (HFpEF).
- To discuss potential therapeutic strategies tailored to specific HFpEF phenotypes.
- To highlight the importance of phenotyping for advancing HFpEF treatment.
Main Methods:
- Literature review of current research on HFpEF phenotypes.
- Analysis of clinical, pathophysiological, and biomarker data for patient categorization.
- Synthesis of information on existing and emerging treatment strategies.
Main Results:
- HFpEF exhibits significant heterogeneity, with distinct phenotypes influenced by comorbidities, imaging, hemodynamics, and biomarkers.
- No universal consensus exists for categorizing HFpEF patients into specific phenogroups.
- Several potential therapeutic avenues are being explored based on underlying pathophysiological mechanisms.
Conclusions:
- Phenotypic categorization of HFpEF patients is crucial for developing targeted and effective treatments.
- Further research is needed to establish a standardized approach to HFpEF phenotyping.
- Personalized medicine approaches hold promise for improving outcomes in HFpEF.
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